The Reichenberger laboratory is interested in learning
about the complex processes required for generating and
maintaining the skin and bones. Primarily, we study human
genetic disorders in which dermal wound healing and bone
remodeling are disrupted.
Current projects include identification of genes that
cause keloids, a wound healing disorder, and analysis of
mouse models for rare genetic bone disorders, cherubism and
craniometaphyseal dysplasia (CMD). We take multidisciplinary
approaches to identify mechanisms that lead to those
disorders. We are further interested in the genetic origin
of other bone disorders, such as aplasia cutis congenita
(ACC).
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Ueki Y, Lin C; Senoo M, Ebihara T, Agata N, Onji M,
Saheki Y, Kawai T, Mukherjee PM, Reichenberger E, and Olsen
BR (2007)
Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in Sh3bp2 "cherubism"
mice. Cell 128 (1), 71-83. PMID: 17218256
Islam M, Lurie AG, and Reichenberger E (2005)
Clinical
features of Tricho-Dento-Osseous syndrome and presentation
of three new cases: an addition to clinical heterogeneity.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 100(6):
736-742.
Jafarov T, Ferimazova N, and Reichenberger E (2005)
Noonan-like Syndrome/cherubism patients with mutations in
PTPN11. Clin Genet. 68(2):190-191.
Marneros AM, Norris JEC, Watanabe S, Reichenberger E,
Olsen BR (2004)
Genome Scans provide evidence for keloid
susceptibility loci on chromosomes 2q23 and 7p11.
Investigative J. of Dermatology 122(5):1126-32.
Messadi D, Doung HS, Zhang Q, Kelly AP, Tuan TL,
Reichenberger E, and Le AD (2004)
Activation of NF-kB
Signal Pathways in Keloid Fibroblasts. Arch Dermatol Res.
296(3):125-33.
Ueki Y, Tiziani V,Santanna C, Maulik C, Garfinkle J,
Ninomiya C, doAmaral C, Peters H, Habal M, Rhee-Morris L,
Doss JB, Kreiborg S, Olsen BR, and Reichenberger E (2001)
Mutations in the c-Abl- binding protein SH3BP2 cause
excessive bone degradation in cherubism. Nature Genetics
28(2):125-126.
Reichenberger E, Tiziani V, Watanabe S, Park L, Ueki Y,
Santanna C, Baur S, Shiang R, Grange DK, Beighton P, Lidral
A, Gorlin RJ, Raposo doAmaral C, Mulliken JB, and Olsen BR
(2001).
Autosomal dominant craniometaphyseal dysplasia (CMD)
is caused by mutations in the transmembrane protein ANK. Am
J Hum Genet 68(6):1321-1326.
View more publications, see
Pubmed listing.
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"Molecular Mechanisms for Keloid Formation,"
E. Reichenberger, P.I., NIH/NIAMS, May 1, 2007 to April 30, 2012.
The goal of this project is to identify and characterize
multiple genes responsible for familial keloid formation by
linkage analysis and positional candidate gene cloning.
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Additional Affiliations
Ernst Reichenberger holds a joint appointment in the
Department of Genetics and Developmental Biology, University
of Connecticut School of Medicine. He is also a member of
the New England
Musculoskeletal Institute and the
UConn Stem Cell
Institute.
Student and Postdoctoral Research Opportunities
Ernst Reichenberger is a faculty member in the
Skeletal,
Craniofacial, and Oral Biology Graduate Program and
the
Master of Dental Science (MDentSc) Program.
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