In Vivo Imaging Suite
A component of the New England Musculoskeletal Institute,  this facility enables live, three-dimensional imaging of musculoskeletal development of the mouse, via 15 micron resolution of developing bone using a Scanco VivaCT40 scanner and dedicated morphometric/densitometric analysis software; temporal digital capture of multiple bioluminescent and transmission/reflectance fluorescent reporters achieved at 20 micron resolution using a Caliper Life Sciences IVIS Spectrum 200 Lumina imaging system; and post-surgical and/or longitudinal radiographs acquired in real time using the Faxitron MX-20 digital X-ray system.

Viral Vector Core
A UConn Health Center-supported facility providing support for generation of retroviral, adenoviral and lentiviral vectors, particularly for use in hESC work; and support for generation of human induced pluripotent stem cells.

MicroCT Facility
A component of the New England Musculoskeletal Institute, this facility contains a Scanco µCT40 and Stratec 960M pQCT for quantitative ex vivo measurements of bone mass, and instrumentation for mechanical testing of mouse bone.

Cartilage Repair Core
A joint venture with the New England Musculoskeletal Institute, this facility is developing models of cartilage repair in animals and in tissue from human patients obtained from knee joint replacement

Biomechanics Core
A component of the New England Musculoskeletal Institute, this facility provides testing of strength and quality of bone and cartilage tissue after repair or regeneration.

Bone Histology and Histomorphometry Center
A component of the New England Musculoskeletal Institute, this facility provides preparation and analysis of bone tissue by histology and cryohistology.

Biomaterials Facilities
The Center for Biomaterials contains equipment including a Hitachi H-10 Scanning electron microscope for biomaterial surface structure, FTIR equipped microscope for spectral visualization of biomaterials including cell matrices, BOSE and MTS equipment for biomaterial fatigue testing.

Stem Cell Core
Contained within the UConn Stem Cell Institute, this facility provides support for generation and maintenance of human embryonic stem cells and human induced pluripotent stem cells, including training to investigators in stem cell culture, colony picking, and karyotyping, and specialized equipment including a copper jacketed multi door Heraeus 6220 CO2 incubator with the O2 capability, class 2 tissue culture hood, a liquid nitrogen tank, an Olympus CK2 inverted microscope for routine monitoring of cultures, and a Nikon SMZ800 fluorescence steromicroscope and sterile enclosure for colony picking, fluorescence photography of GFP-marked hESC.

Translational Genomics Core
A UConn Health Center-supported facility offering a variety of microarray services for monitoring gene and microRNA expression, genotyping, and DNA methylation. Microarray sequencing provided by Affymetrix platform with GeneChip® high resolution Scanner 3000, upgraded to 7G for 1 micron resolution and Fluidics 450 Workstation and hybridization oven, and Illumina platform containing the Beadstation 500G scanner, microplate shaker, two incubation ovens and Tecan slike washing station. Also a new generation Illumina Genome Analyzer for runs of 1 billion bases which catalogue an entire transcriptome of a cell type with high fidelity and accuracy.

Flow Cytometry Center
A UConn Health Center-supported facility providing analysis and sorting of cells including human stem cells, expressing multiplexed fluorescent or cell surface markers, using FACS lasers which excite multiple GFPs including red, sapphire and cyan.

Center for Cell Analysis and Modeling (CCAM)
One of five national Technology Centers for Networks and Pathways supported by the NIH Roadmap Initiatives for Medical Research, it offers the “Virtual Cell” software and provides fluorescent imaging via three confocal and a two photon microscopes, and houses a Molecular Dynamics phosphorimager and fluorimager and two high resolution cameras (color and B/W) for digital photography of research data.

Gregory P. Mullen NMR Structural Biology Facility
A UConn Health Center-supported facility providing state-of-the-art environment for studying the three-dimensional structure, dynamics, folding, and interactions of biological macromolecules. Equipped with Varian INOVA quadruple resonance spectrometers, a Jasco 710 spectropolarimeter, multi angle light scattering facility and Linux servers and workstations.

Proteomics and Biological Mass Spectrometry Facility
A UConn Health Center-supported facility offering proteomics analysis of cell or tissue samples by offering state-of-the-art equipment and proteomics expertise in preparing, sequencing and analyzing gel samples.

Gene Transfer and Transgenic Facility
A UConn Health Center-supported, accredited, barrier facility dedicated to all aspects of mouse breeding and maintenance and providing production of transgenic mice, gene knockouts and conditional deletions, maintained on an interactive Filemaker data base.